Priligy online proofed2019-02-06
Priligy (Dapoxetine) for Premature Ejaculation Treatment. What Is It and Does It Work?
Studies have revealed that premature ejaculation (PE) is the most prevalent sexual disorder amongst men. This is a condition where a man reaches orgasm too soon following the beginning of the intercourse. Although the definition can be subject to multiple interpretations, all with a certain degree of vagueness, the importance of PE medication cannot be downplayed.
Priligy has marked its place in history as the first-ever medication to be manufactured for primarily treating premature ejaculation. This med contains dapoxetine as its active ingredient.
What Is Dapoxetine
Dapoxetine is a drug that belongs to the class of selective serotonin reuptake inhibitors (SSRIs). The SSRIs are commonly used in clinical practice as antidepressants. When dapoxetine was manufactured for the first time by Eli Lilly Pharmaceutical Company, it was intended to be a new antidepressant on the market. However, it didn’t turn out to be a very good antidepressant as the makers had anticipated. The clinical trials were halted momentarily, but the drug later came back as the treatment for premature ejaculation. It is known that antidepressants can be used off-label as meds for premature ejaculation. However, dapoxetine comes a drug intended solely for PE treatment, unlike the other SSRIs.
Eli Lilly later sold its patent for dapoxetine to Johnson & Johnson. The drug is currently manufactured by a number of pharma companies and marketed in many parts of the world after getting approval from the respective regional authorities. However, dapoxetine is yet to be approved by the US FDA.
How Dapoxetine Works
Dapoxetine, like all the other SSRIs, affects the reuptake of serotonin at the synapses. Serotonin is a chemical compound that is used to relay messages in the central nervous systems. Synapses are structures linking two nerves.
Ejaculation is a function of the sympathetic nervous system. This system is also known to control fight or flight especially when one is in danger. Dapoxetine delays the nerve signals that trigger ejaculation by increasing the levels of serotonin at the synapses.
Dapoxetine is marketed under different trade names. The original brand-name dapoxetine, for example, is available as Priligy. Currently, Priligy is owned by ALZA Corp which is a part of Johnson & Johnson.
Priligy online comes in the form of film-coated grey tablets which are round and convex. The tablets are available in strengths of 30mg and 60mg (the strength is embossed on one side of the pill inside a triangle). The tablets are packaged in child-resistant blisters.
Apart from dapoxetine, Priligy also contains a number of excipients, such as lactose, magnesium, cellulose, and sodium.
Generic dapoxetine’ is a term used to refer to all the other dapoxetine-based meds that are not manufactured by Johnson & Johnson. The generic versions come under many different brands including but not limited to:
- Ever Long
Most of the generic dapoxetine versions are sold in strengths of 30mg and 60mg just like the brand-name meds. As of now, the meds are only available in the form of oral tabs.
The branded pills can be bought at $8 per tablet whereas one generic tab will cost you 2 dollars or less depending on the quantity of your purchase and the seller. You will find many generic versions of Priligy being sold in online pharmacies. Always do your background research before buying generic dapoxetine online because on some less reliable websites you might run into counterfeits.
Does Dapoxetine Work?
Several studies have been carried out to investigate the effectiveness of dapoxetine. The parameter that is commonly used to assess the role of dapoxetine is the intravaginal ejaculatory latent time, abbreviated as IELT. This is the time between penetration and ejaculation. When the IELT is less than two minutes, it is termed premature ejaculation.
In one study, the subjects who had PE showed an average IELT of 0.9 minutes before taking dapoxetine. After using 30mg dapoxetine, the mean IELT was found to be 3.1 minutes whereas the 60mg strength raised the time to 3.6 minutes. A significant percentage also reported that they could control ejaculation after taking the drug.
Many online reviews also support the fact that dapoxetine is effective in treating premature ejaculation. It is worth noting that dapoxetine does not treat the underlying cause of premature ejaculation and it is more of a symptom reliever. This is why it is a use-as-needed medication. Dapoxetine should be taken between one to three hours before sexual intercourse. It is not affected by food intake, and only a single dose should be taken within a period of 24 hours. The medication is safe for people between the age of 18 and 64 years.
The side effects commonly associated with dapoxetine include headaches, tremors, dry mouth, diarrhea, somnolence, fatigue, nausea, and dizziness. These side effects can increase in severity and frequency with a higher dose. Therefore, it is advised that you start with the 30mg strength and only go up to 60mg if you don’t get satisfactory results.
There are rare cases of allergies when the body responds to the components of the medication with a hypersensitivity reaction. This usually presents with itching, skin rash, shortness of breath and facial swelling.
Dapoxetine should not be used by people who have cardiovascular conditions such as valvular heart diseases, heart failure, and conduction anomalies. The drug is also contraindicated in people using monoamine oxidase inhibitors (MAOIs) such as selegiline. Moreover, dapoxetine should not be used by individuals taking other SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs) or tricyclic antidepressants (TCAs) because this leads to an increased risk of adverse effects.
The Concomitant Use of Dapoxetine and PDE 5 Inhibitors
The use of dapoxetine together with PDE 5 inhibitors is very popular. PDE 5 inhibitors include sildenafil, tadalafil, avanafil and vardenafil. When these meds are combined, they treat both erectile dysfunction and premature ejaculation.
It has been shown that dapoxetine does not affect the pharmacokinetics of PDE 5 inhibitors significantly. Therefore, taking the combination is okay but the doses have to be regulated, and it is good if you get advice from your doctor because there is a risk of blood pressure fluctuations associated with taking these meds. Currently, pills that contain both dapoxetine and PDE 5 inhibitors are being sold in many online pharmacies making simultaneous use of the two meds both easier and cheaper.
Dapoxetine is a drug licensed to treat premature ejaculation, unlike the others which were always used off-label. This is a medication with proven efficacy, and it offers relief to many whose sex life leaves much to be desired. The presence of generics makes it easily affordable, but the drug also has the potential for abuse by adventurous people who do not suffer from premature ejaculation but want to enhance their already normal sexual performance further.
Cool article, thanks! But could you also add a listing of brands of generic dapo that you’d recommend? There are so many sold online so it’s kinda hard to find the right one.